Oil and gas discovery in Ghana since 2007 has attracted the interest of many international and local actors, including transnational corporations. Contrary to the expected benefits of oil to broad-based development, the industry has perpetuated exclusion and poverty in communities in the neighbourhood of extractive activities. In particular, the globalized environment which underscores the industry has shaped the governance and benefit-sharing mechanisms to exclude a wide range of local citizens, particularly women, from the actual gains of the industry. This experience is worsened by other ramifications such as water pollution, dwindling fish stock, and overpopulation due to the growth of migrant workers in booming oil towns. This paper utilizes a feminist political ecology framing to examine the gendered disparities in the sharing of benefits and the ramification of these interactions on women’s livelihoods. In particular, the paper relies on data from fieldwork conducted in Ghana in 2019 to explore how the power and agency of varying stakeholders result in differentiated impacts of the hydrocarbon industry on communities. Considering that the gendered impacts of mainstream economies remain poorly understood, this paper contributes to the existing scholarship on both the outcomes of Ghana’s oil and gas industry and feminist political ecology theorizing.